Not known Factual Statements About akorn promethazine codeine
Not known Factual Statements About akorn promethazine codeine
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Anaphylaxis: Anaphylaxis continues to be described with codeine, on the list of ingredients in promethazine HCl and codeine phosphate oral Resolution.
Neuroleptic malignant syndrome (NMS) which may result in Loss of life. Notify your healthcare supplier without delay Should you have any of the next signs or symptoms of NMS:
Life-threatening respiration issues (respiratory melancholy). Promethazine Hydrochloride and Codeine Phosphate Oral Option might cause respiratory troubles (respiratory despair) that can take place at any time in the course of treatment and may result in death. Your threat of respiration troubles is greatest after you first start out taking Promethazine Hydrochloride and Codeine Phosphate Oral Remedy, are getting other medicines that might cause respiratory difficulties, have specific lung troubles, are aged or have specified other health problems.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are sophisticated, demanding cautious thing to consider of the effects over the father or mother drug, codeine, and the Energetic metabolite, morphine.
Overdose of codeine in Grownups is affiliated with lethal respiratory despair, and using codeine in children more youthful than twelve decades of age has been linked to lethal respiratory despair when utilised as advised [see Warnings and Safeguards (five.
Results around the Cardiovascular Program Codeine provides peripheral vasodilation which may lead to orthostatic hypotension or syncope. Manifestations of histamine launch and/or peripheral vasodilation may perhaps include things like pruritus, flushing, red eyes and sweating and/or orthostatic hypotension.
A household teaspoon will not be an correct measuring gadget and may lead to overdosage [see Warnings and Safeguards (five.7)]. For prescriptions where by a measuring system just isn't presented, a pharmacist click here can provide an proper measuring machine and can provide instructions for measuring the correct dose. Will not overfill. Rinse the measuring device with water just after Just about every use.
five.eight Activities Demanding Psychological Alertness: Threats of Driving or Functioning Equipment Codeine and promethazine, two on the Energetic components in promethazine HCl and codeine phosphate oral Remedy, might generate marked drowsiness and impair the mental and/or Actual physical skills required for your functionality of potentially hazardous duties which include driving an automobile or operating machinery.
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Offering or giving freely Promethazine with Codeine Oral Alternative could harm Other individuals, and is against the legislation. Explain to your healthcare provider When you've got at any time abused or been dependent on Liquor, prescription medicines or Road medicines. Promethazine with Codeine Oral Answer isn't for youngsters under six years of age.
Promethazine Promethazine competitively antagonize H1 receptors situated in the majority of the easy muscle such as the gastrointestinal tract, uterus, massive blood vessels and bronchial muscle mass.
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Postmarketing situations of respiratory depression, including fatalities are actually described with utilization of promethazine in pediatric clients.